Guided by the Whole School, Whole Community, Whole Child model, the goal of this proposed Project MOVE (Minority Obesity Vanquished with Education) is to determine the efficacy of a Head Start center-based and home-based physical activity intervention on racially, ethnically, and socioeconomically disadvantaged preschoolers’ health outcomes. Aimed at achieving health equity, Project MOVE is designed to create and sustain a comprehensive, developmentally, and culturally appropriate physical activity intervention that may be implemented with underserved preschoolers in 14 Head Start centers.